Advances in pathogenesis and clinical features of HIV-associated neuroretinal disorder
10.3980/j.issn.1672-5123.2022.4.14
- VernacularTitle:HIV相关视网膜神经病变发病机制及临床特点的研究进展
- Author:
Yue Zou
1
Author Information
1. 1Department of Ophthalmology, Affiliated Hospital of Yunnan University, Kunming 650021, Yunnan Province, China|2Yunnan Eye Disease Clinical Medical Center, Kunming 650021, Yunnan Province, China|3Yunnan Eye Disease Clinical Medical Research Center, Kunming 650021, Yunnan Province, China
- Publication Type:Review
- Keywords:
human immunodeficiency virus(HIV);
neuroretinal disorder;
clinical features
- From:
International Eye Science
2022;22(4):597-600
- CountryChina
- Language:Chinese
-
Abstract:
Ocular diseases in human immunodeficiency virus(HIV)infected patients have attracted increasing attention due to their impact on quality of life. As HIV treatment continues to improve, opportunistic eye infections are decreasing, while HIV-associated retinopathy is becoming a growing concern. HIV-associated retinopathy, including a series of structural changes in the retina and optic nerves(thinning of the nerve fiber layer, changing in blood vessels), has been found to cause decreased visual sensitivity, visual field defect, color vision disorder. However, the pathogenesis of HIV-associated neuroretinal disorder has not been fully clarified, and the existing findings may be related to direct destruction of retinal optic nerve tissue by HIV virus, chronic inflammation, and destruction of the blood-retina barrier. Understanding the pathological characteristics and possible mechanisms of HIV-associated neuroretinal disorder is expected to provide new ideas and approaches for the treatment of the disease and improve the quality of life of HIV-infected patients.
- Full text:202204014.pdf
