Ginsenoside Rg1 ameliorates blood-brain barrier disruption and traumatic brain injury

Author: Kefeng ZHAI ¹ ; Hong DUAN ¹ ; Wei WANG ¹ ; Siyu ZHAO ¹ ; Ghulam Jilany KHAN ² ; Mengting WANG ¹ ; Yuhan ZHANG ¹ ; Kiran THAKUR ³ ; Xuemei FANG ¹ ; Chao WU ¹ ; Jianbo XIAO ⁴ ; Zhaojun WEI ³
Author Information

1. Suzhou Engineering Research Center of Natural Medicine and Functional Food, School of Biological and Food Engineering, Suzhou University, Suzhou 234000, China.
2. Department of Pharmacology and Therapeutics, Faculty of Pharmacy, University of Central Punjab, Lahore 54000, Pakistan.
3. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
4. Department of Analytical Chemistry and Food Science, Faculty of Food Science and Technology, University of Vigo-Ourense Campus, Ourense E-32004, Spain.
Publication Type:Journal Article
Keywords: Blood–brain barrier; Exosome; Ginsenoside Rg1; MiRNA-21; Nonmuscle myosin IIA; Traumatic brain injury
From: Acta Pharmaceutica Sinica B 2021;11(11):3493-3507
CountryChina
Language:English
Abstract: During the traumatic brain injury (TBI), improved expression of circulatory miR-21 serves as a diagnostic feature. Low levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and blood-brain barrier (BBB) permeability, reduce nerve apoptosis, restore neural function and ameliorate TBI. We evaluated the role of macrophage derived exosomes-miR-21 (M-Exos-miR-21) in disrupting BBB, deteriorating TBI, and Rg1 interventions. IL-1