Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway.

Author: Xiangjin ZHENG ¹ ; Wan LI ¹ ; Huanli XU ² ; Jinyi LIU ¹ ; Liwen REN ¹ ; Yihui YANG ¹ ; Sha LI ¹ ; Jinhua WANG ¹ ; Tengfei JI ³ ; Guanhua DU ¹
Author Information

1. The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
2. Department of Pharmacology, Capital Medical University, Beijing 100069, China.
3. Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Publication Type:Journal Article
Keywords: Anti-inflammation; Apoptosis; Autophagy; G2/M phase; GBM; SW33; Safety; mTOR
From: Acta Pharmaceutica Sinica B 2021;11(11):3465-3480
CountryChina
Language:English
Abstract: Glioblastoma multiforme (GBM) in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it. Studies of sinomenine, an alkaloid from the Chinese medicinal plant,