TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor.

Author: Tingting PENG ¹ ; Yao HUANG ² ; Xiaoqian FENG ² ; Chune ZHU ³ ; Shi YIN ² ; Xinyi WANG ⁴ ; Xuequn BAI ² ; Xin PAN ² ; Chuanbin WU ¹
Author Information

1. College of Pharmacy, Jinan University, Guangzhou 510632, China.
2. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
3. School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
4. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
Publication Type:Journal Article
Keywords: Chemotherapy; Dissolving microneedles; Functionalized PLGA nanoparticles; Hyaluronic acid; Photothermal therapy; Superficial tumor; TPGS
From: Acta Pharmaceutica Sinica B 2021;11(10):3297-3309
CountryChina
Language:English
Abstract: Nanoparticles (NPs) have shown potential in cancer therapy, while a single administration conferring a satisfactory outcome is still unavailable. To address this issue, the dissolving microneedles (DMNs) were developed to locally deliver functionalized NPs with combined chemotherapy and photothermal therapy (PTT).