Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence.

Author: Xiu HAN ¹ ; Xiang XU ¹ ; Ziheng WU ² ; Zhenghong WU ¹ ; Xiaole QI ¹
Author Information

1. Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.
2. Parkville Campus, Monash University, VIC 3052, Australia.
Publication Type:Journal Article
Keywords: Biocompatibility; Cancer; DNA tetrahedron; Endosomal escape; Gene delivery; Gene silence; i-motif; siRNA
From: Acta Pharmaceutica Sinica B 2021;11(10):3286-3296
CountryChina
Language:English
Abstract: The functionality of DNA biomacromolecules has been widely excavated, as therapeutic drugs, carriers, and functionalized modification derivatives. In this study, we developed a series of DNA tetrahedron nanocages (Td),