Cytosolic delivery of the immunological adjuvant Poly I:C and cytotoxic drug crystals

Author: Xiaoqing DU ¹ ; Yuqi HOU ¹ ; Jia HUANG ¹ ; Yan PANG ¹ ; Chenlu RUAN ¹ ; Wei WU ² ; Chenjie XU ³ ; Hongwei ZHANG ⁴ ; Lifang YIN ¹ ; Wei HE ¹
Author Information

1. Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
2. Key Laboratory of Smart Drug Delivery of Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai 201203, China.
3. Department of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR, China.
4. Department of Pharmaceutical Sciences, School of Pharmacy-Boston, MCPHS University, Boston, MA 02115, USA.
Publication Type:Journal Article
Keywords: Asynchronous release; Cancer cells; Chemoimmunotherapy; Co-delivery; Immunogenicity; Immunostimulant; Paclitaxel
From: Acta Pharmaceutica Sinica B 2021;11(10):3272-3285
CountryChina
Language:English
Abstract: Co-delivery of chemotherapeutics and immunostimulant or chemoimmunotherapy is an emerging strategy in cancer therapy. The precise control of the targeting and release of agents is critical in this methodology. This article proposes the asynchronous release of the chemotherapeutic agents and immunostimulants to realize the synergistic effect between chemotherapy and immunotherapy. To obtain a proof-of-concept, a co-delivery system was prepared