Cancer-specific calcium nanoregulator suppressing the generation and circulation of circulating tumor cell clusters for enhanced anti-metastasis combinational chemotherapy.
10.1016/j.apsb.2021.04.009
- Author:
Dan LI
1
;
Yingli WANG
1
;
Chang LI
1
;
Qiu WANG
1
;
Bingjun SUN
1
;
Haotian ZHANG
2
;
Zhonggui HE
1
;
Jin SUN
1
Author Information
1. Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- Keywords:
Breast cancer;
CI, combination index;
CLSM, confocal laser scanning microscopy;
CTC, circulating tumor cell;
Cell–cell junctions;
Circulating tumor cell clusters;
DAPI, 4ʹ,6-diamidino-2-phenylindole;
DIG, digoxin;
DLS, dynamic light scattering;
DOX, doxorubicin;
DiR, 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyaineiodide;
Digoxin;
Doxorubicin;
EMT, epithelial–mesenchymal transition;
Epithelial–mesenchymal transition;
H&E, hematoxylin and eosin;
Homologous targeting;
Lung metastasis;
MMP-9, matrix metalloproteinase-9;
MTT, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazoliumbromide;
TEM, transmission electron microscopy
- From:
Acta Pharmaceutica Sinica B
2021;11(10):3262-3271
- CountryChina
- Language:English
-
Abstract:
Tumor metastasis is responsible for chemotherapeutic failure and cancer-related death. Moreover, circulating tumor cell (CTC) clusters play a pivotal role in tumor metastasis. Herein, we develop cancer-specific calcium nanoregulators to suppress the generation and circulation of CTC clusters by cancer membrane-coated digoxin (DIG) and doxorubicin (DOX) co-encapsulated PLGA nanoparticles (CPDDs). CPDDs could precisely target the homologous primary tumor cells and CTC clusters in blood and lymphatic circulation. Intriguingly, CPDDs induce the accumulation of intracellular Ca
