Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy.
10.1016/j.apsb.2021.05.005
- Author:
Hao REN
1
;
Jiahui YONG
1
;
Qingqing YANG
1
;
Zhen YANG
1
;
Zhangya LIU
1
;
Yan XU
1
;
Hao WANG
1
;
Xing JIANG
2
;
Wenjun MIAO
1
;
Xueming LI
1
Author Information
1. School of Pharmaceutical Science, Nanjing Tech University, Nanjing 211816, China.
2. School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, China.
- Publication Type:Journal Article
- Keywords:
ALP, alkaline phosphatise;
ALT, alanine transaminase;
AST, aspartate aminotransferase;
ATP, adenosine triphosphate;
BUN, blood urea nitrogen;
CDT, chemodynamic therapy;
CLSM, confocal laser scanning microscope;
CREA, creatinine;
CRT, calreticulin;
CTLA-4, cytotoxic T-lymphocyte-associated protein 4;
CTLs, cytotoxic T lymphocytes;
Cancer immunotherapy;
Ce6, Chlorin e6;
DAMPs, damage-related molecular patterns;
DAPI, 2-(4-amidinophenyl)-6-indolecarbamidine dihydrochloride;
DCs, dendritic cells;
DLS, dynamic light scattering;
DMPO, dimethyl pyridine N-oxide;
EDC, 1-ethyl-3-(3ʹ-dimethylaminopropyl) carbodiimide;
EDS, energy-dispersive spectrometry;
EPR, enhanced permeability and retention;
ESR, electron spin resonance;
FG, FeS-GOx nanodots;
FGP, FeS-GOx@PTX nanoparticles;
FITC, fluorescein Isothiocyanate;
FeCl2·4H2O, iron dichloride tetrahydrate;
FeS-based cascade bioreactor;
GOx, glucose oxidase;
Glu, glucose;
Glucose oxidase;
H&E, hematoxylin and eosin;
H2DCFDA, 2,7-dichlorodihydrofluorescein acetoacetic acid;
HMGB-1, high mobility group box protein 1;
HPF, 2-[6-(4,-hydroxy) phenoxy-3H-xanthene-3-on-9-yl;
HSA, human serum albumin;
ICB, immune checkpoint blockade;
ICD amplifier;
ICD, immunogenic cell death;
IFN-γ, interferon-γ;
MB, methylene blue;
MCTS, multicellular tumor spheroids;
MFI, median fluorescence Intensity;
Metastasis inhibition;
NHS, N-hydroxy succinimide;
Na2S, sodium sulfide;
OH, hydroxyl;
PBS, phosphate buffer saline;
PTT, photothermal therapy;
PTX, paclitaxel;
ROS, reactive oxygen species;
SEM, scanning electron microscope;
Synergistic therapy;
TAA, tumor-associated antigens;
TDLN, tumor-draining lymph nodes;
TEM, transmission microscope;
TMB, 3,3ʹ,5,5ʹ-tetramathylbenzidine;
TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labelling;
Tumor penetration;
XPS, X-ray photoelectron spectroscopy;
XRD, X-ray diffraction patterns
- From:
Acta Pharmaceutica Sinica B
2021;11(10):3244-3261
- CountryChina
- Language:English
-
Abstract:
Major challenges for cancer treatment are how to effectively eliminate primary tumor and sufficiently induce immunogenic cell death (ICD) to provoke a robust immune response for metastasis control. Here, a self-assembled cascade bioreactor was developed to improve cancer treatment with enhanced tumor penetration and synergistic therapy of starvation, chemodynamic (CDT) and photothermal therapy. Ultrasmall FeS-GOx nanodots were synthesized with glucose oxidase (GOx) as template and induced by paclitaxel (PTX) to form self-assembling FeS-GOx@PTX (FGP)
