Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections.

Author: Liting CHENG ¹ ; Miao-Miao NIU ² ; Tong YAN ¹ ; Zhongyi MA ¹ ; Kexin HUANG ¹ ; Ling YANG ¹ ; Xin ZHONG ¹ ; Chong LI ¹
Author Information

1. Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
2. Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing 210009, China.
Publication Type:Journal Article
Keywords: Albumin; AmB, amphotericin B; BBB, blood‒brain barrier; BSA, bovine serum albumin; Complex fungal infection; DDS, drug delivery system; IME, infectious microenvironment; MMP-3; MMP-3, matrix metalloproteinase 3; MTN, micro-to-nano; Microenvironment responsive; NP, nanoparticle; PEG, polyethylene glycol; PMVECs, pulmonary microvascular endothelial cells; RFP, red fluorescent protein; SPARC; SPARC, secreted protein acidic and rich in cysteine; Size-tunable strategy
From: Acta Pharmaceutica Sinica B 2021;11(10):3220-3230
CountryChina
Language:English
Abstract: As a typical human pathogenic fungus,