Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development.
10.1016/j.apsb.2021.03.004
- Author:
Yuli WANG
1
;
Xingyan ZHANG
2
;
Yuyan WANG
3
;
Wenjing ZHAO
4
;
Huling LI
2
;
Lixing ZHANG
1
;
Xinping LI
5
;
Tiejun ZHANG
2
;
Hongbing ZHANG
2
;
He HUANG
1
;
Changxiao LIU
2
Author Information
1. Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemistry Engineering and Technology, Tianjin University, Tianjin 300072, China.
2. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193 China.
3. The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Medical Oncology, Beijing Institute of Cancer Research, Beijing 100142 China.
4. Department of Pharmacology, Tianjin Medical University, Tianjin 300070, China.
5. MITRO Biotech Co., Ltd., Nanjing 211100, China.
- Publication Type:Review
- Keywords:
Cancer immunity;
Drug development;
Immune checkpoint;
Immunoregulatory;
Signaling pathway;
Therapeutic target;
Traditional Chinese medicine
- From:
Acta Pharmaceutica Sinica B
2021;11(10):2957-2972
- CountryChina
- Language:English
-
Abstract:
Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance, preventing autoimmune responses, and minimizing tissue damage by regulating the duration and intensity of the immune response. Furthermore, immune checkpoints are usually overexpressed in cancer cells or noninvasive cells in tumor tissues and are capable of suppressing the antitumor response. Based on substantial physiological analyses as well as preclinical and clinical studies, checkpoint molecules have been evaluated as potential therapeutic targets for the treatment of multiple types of cancers. In the last few years, extensive evidence has supported the immunoregulatory effects of traditional Chinese medicines (TCMs). The main advantage of TCMs and natural medicine is that they usually contain multiple active components, which can act on multiple targets at the same time, resulting in additive or synergistic effects. The strong immune regulation function of traditional Chinese medicine on immune checkpoints has also been of great interest. For example,
