Transcriptome sequencing and metabolome analysis reveal the mechanism of Shuanghua Baihe Tablet in the treatment of oral mucositis.
10.1016/S1875-5364(22)60150-X
- Author:
Qi-Shun GENG
1
,
2
;
Rui-Juan LIU
3
;
Zhi-Bo SHEN
4
;
Qian WEI
4
;
Yuan-Yuan ZHENG
4
;
Lan-Qi JIA
4
;
Long-Hao WANG
4
;
Li-Feng LI
4
;
Jun LI
1
,
5
;
Wen-Hua XUE
6
Author Information
1. Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
2. Engineering Laboratory for Digital Telemedicine Service, The first Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
3. Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
4. Engineering Laboratory for Digital Telemedicine Service, The first Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
5. Engineering Laboratory for Digital Telemedicine Service, The first Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: lijun_zdyyxb@163.com.
6. Engineering Laboratory for Digital Telemedicine Service, The first Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: xuewenhua77@163.com.
- Publication Type:Journal Article
- Keywords:
IL-17/TNF signal pathway;
Metabolomics;
Oral mucositis;
Shuanghua Baihe tablet;
Transcriptomics
- MeSH:
Animals;
Drugs, Chinese Herbal;
Metabolome;
Quality of Life;
Rats;
Stomatitis;
Tablets;
Transcriptome
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(12):930-943
- CountryChina
- Language:English
-
Abstract:
Oral mucositis (OM) caused by cancer therapy is the most common adverse reaction in the radiotherapy of head and neck tumors. In severe cases, it can lead to the interruption of treatment, which affects the control of the disease and the quality of life. Shuanghua Baihe Tablet (SBT) is a traditional Chinese medicine (TCM) formula, which is administerd to treat OM in China. It has been clinically effective for more than 30 years, but the underlying mechanism is not completely understood. With the development of multiple omics, it is possible to explore the mechanism of Chinese herbal compound prescriptions. Based on transcriptomics and metabolomics, we explored the underlying mechanism of SBT in the treatment of OM. An OM model of rats was established by 5-FU induction, and SBT was orally administered at dosages of 0.75 and 3 g·kg
