Distinctive quality control method for solid-state fermented Isaria cicadae from strain Ic-17-7 and application in a rat model of type 2 diabetes.
10.1016/S1875-5364(21)60113-9
- Author:
Chang-Sheng SUN
1
,
2
;
Yu-Qin WANG
3
;
Zhong-Liang ZHANG
4
;
Yuligh LIOU
1
,
5
;
Hong-Hao ZHOU
1
,
6
,
7
,
8
Author Information
1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
2. China Zhejiang Bioasia Life Science Institute, Pinghu 314200, China.
3. China Zhejiang Bioasia Life Science Institute, Pinghu 314200, China. Electronic address: wyq@bioasia.com.cn.
4. China Zhejiang Bioasia Life Science Institute, Pinghu 314200, China.
5. Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
6. Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China
7. Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, China
8. National Clinical Research Center for Geriatric Disorders, Changsha 410008, China. Electronic address: 801004@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Adenosine;
Blood glucose and lipid;
HEA;
Isaria cicadae;
Quality control;
Type 2 diabetes model
- MeSH:
Animals;
Blood Glucose;
Cordyceps;
Diabetes Mellitus, Type 2/drug therapy*;
Metformin;
Quality Control;
Rats;
Rats, Wistar
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(12):921-929
- CountryChina
- Language:English
-
Abstract:
This work was aimed to establish a quality control method for evaluating the effects on glucose and lipids of the fruiting body of Isaria cicadae Miquel from strain Ic-17-7 (Ic-17-7fb) using a rat model of type 2 diabetes (T2DM). Random amplified polymorphic DNA, sequence-characterized amplified region, and high-performance liquid chromatography (HPLC) were used for the quality control of Ic-17-7fb. The pharmacological effects on streptozocin (STZ)-induced high fat diet (HFD)-fed Albino Wistar rats were evaluated. The rats underwent the following treatments: control, metformin, Ic-17-7fb (0.166 and 0.5 g·kg
