Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment.
10.1016/S1875-5364(21)60111-5
- Author:
Xiao-Long HU
1
;
Wei SHEN
1
;
Rong WANG
1
;
Huan LONG
1
;
Quan WANG
1
;
Jia-Hao FENG
1
;
Thi-Anh PHAM
1
;
Fei XIONG
2
;
Wen-Cai YE
3
;
Hao WANG
4
Author Information
1. State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
2. State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
3. Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China.
4. State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: wanghao@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Activated spleen cells;
Eucalyptin C;
Immunosuppressive effects;
Phloroglucinol-sesquiterpene adducts;
Phosphoinositide 3-kinase-γ (PI3Kγ)
- MeSH:
Animals;
Eucalyptus;
Flavonoids;
Fruit;
Mice;
Molecular Docking Simulation;
Phosphoinositide-3 Kinase Inhibitors
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(11):844-855
- CountryChina
- Language:English
-
Abstract:
The fruits of Eucalyptus globulus Labill. are known to have a plenty of medicinal properties, such as anti-tumor, anti-inflammatory, and immunosuppressive activity. Our previous study found that the phloroglucinol-sesquiterpene adducts in the fruits of E. globulus were immunosuppressive active constituents, especially Eucalyptin C (EuC). Phosphoinositide 3-kinases-γ (PI3Kγ) plays a pivotal role in T cell mediated excessive immune responses. In this study, EuC was first discovered to be a novel selective PI3Kγ inhibitor with an IC
