Immunomodulatory effects of flazin from Crassostrea sikamea on splenic lymphocytes of Sprague-Dawley rats.
10.1016/S1875-5364(21)60119-X
- Author:
Ying KONG
1
;
Li-Hua WANG
1
;
Lei LIU
2
;
Li-Hua ZHENG
3
,
4
;
Yong-Li BAO
3
,
4
;
Xiu-Xian LIU
5
;
Shu-Yue WANG
3
,
6
;
Zhen-Bo SONG
3
,
7
Author Information
1. National Engineering Laboratory for Druggable Gene and Protein Screening, School of Life Sciences, Northeast Normal University, Changchun 130024, China.
2. NMPA Key Laboratory for Quality Control of Cell and Gene Therapy Medicine Products, Northeast Normal University, Changchun 130117, China.
3. National Engineering Laboratory for Druggable Gene and Protein Screening, School of Life Sciences, Northeast Normal University, Changchun 130024, China
4. NMPA Key Laboratory for Quality Control of Cell and Gene Therapy Medicine Products, Northeast Normal University, Changchun 130117, China.
5. School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
6. NMPA Key Laboratory for Quality Control of Cell and Gene Therapy Medicine Products, Northeast Normal University, Changchun 130117, China. Electronic address: wangsy171@nenu.edu.cn.
7. NMPA Key Laboratory for Quality Control of Cell and Gene Therapy Medicine Products, Northeast Normal University, Changchun 130117, China. Electronic address: songzb484@nenu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Crassostrea sikamea;
Cytokine secretion;
Flazin;
Immunomodulatory effect;
Splenic lymphocyte
- MeSH:
Animals;
Carbolines;
Crassostrea;
Furans;
Lymphocytes;
Rats;
Rats, Sprague-Dawley;
Spleen
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(11):836-843
- CountryChina
- Language:English
-
Abstract:
Crassostrea sikamea (C.sikamea) is an important edible and medicinal seafood in China. In the present study, a compound named flazin was separated and identified from the ethyl acetate extract of C.sikamea (EAECs) for the first time. In addition, the 3-(4, 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetra zolium (MTS) assay revealed that EAECs and flazin inhibited the transformation of splenic lymphocytes in vitro. Moreover, flazin (20 μg·mL
