Bioactive sesquineolignans from the twigs of Litsea cubeba.
10.1016/S1875-5364(21)60075-4
- Author:
Huan XIA
1
,
2
;
Gui-Yang XIA
1
,
2
;
Ling-Yan WANG
3
;
Min WANG
4
;
Ya-Nan WANG
3
;
Peng-Cheng LIN
5
;
Sheng LIN
1
,
6
Author Information
1. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
4. College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China.
5. College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China. Electronic address: qhlpc@126.com.
6. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: lsznn@126.com.
- Publication Type:Journal Article
- Keywords:
Litsea cubeba;
NO production inhibitory activity;
Sesquineolignans
- MeSH:
Litsea;
Macrophages;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(10):796-800
- CountryChina
- Language:English
-
Abstract:
In a continuing search for biological natural products with structure diversity from traditional Chinese herbs, five new sesquineolignans (1-5) were isolated from an ethyl acetate extract of the twigs of Litsea cubeba. Their structures were elucidated based on MS, 1D and 2D NMR spectroscopic data, as well as experimental electronic circular dichroism (ECD) spectra. Compounds 1-5 showed moderate inhibitory effects against LPS-induced NO production in RAW264.7 macrophages, with IC
