Effects of chitooligosaccharide-zinc on the ovarian function of mice with premature ovarian failure via the SESN2/NRF2 signaling pathway.
10.1016/S1875-5364(21)60084-5
- Author:
Jia LI
1
,
2
;
Yu-Hang CHEN
3
;
Jia-Yu XU
4
;
Jiang-Ying LIU
4
;
Jia-Cheng FU
3
;
Xiu-Ping CAO
5
;
Jian HUANG
1
,
2
;
Yue-Hui ZHENG
6
,
7
Author Information
1. Medical Experimental Teaching Center, Nanchang University, Nanchang 330006, China
2. Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang University, Nanchang 330006, China.
3. The Second Clinical Medical College, Nanchang University, Nanchang 330006, China.
4. The First Clinical Medical College, Nanchang University, Nanchang 330006, China.
5. School of Basic Medicine, Nanchang University, Nanchang 330006, China.
6. Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China
7. Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang University, Nanchang 330006, China. Electronic address: yuehuizheng@163.com.
- Publication Type:Journal Article
- Keywords:
Aging;
Chitooligosaccharide-zinc;
Ovarian function;
Premature ovarian failure;
Sestrin2-nrf2
- MeSH:
Animals;
Chitosan;
Female;
Humans;
Mice;
NF-E2-Related Factor 2/genetics*;
Nuclear Proteins;
Oligosaccharides;
Primary Ovarian Insufficiency/drug therapy*;
Signal Transduction;
Zinc
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(10):721-731
- CountryChina
- Language:English
-
Abstract:
Chitooligosaccharide-zinc (COS·Zn) is a powerful anti-oxidant and anti-aging scavenger, whose anti-oxidative ability immensely exceeds vitamin C. Therefore, this study was aimed to investigate the protective effects of COS·Zn against premature ovarian failure (POF) and potential mechanisms. Female KM adult mice were divided into the following groups: a treatment group (150 mg·kg
