Distribution and infectious characteristics of re-positive cases infected with SARS-CoV-2.
10.3760/cma.j.cn112338-20210506-00367
- Author:
ZhiLi LI
1
;
Yu LI
1
;
QiuLan CHEN
1
;
XiaoKun YANG
1
;
HongTing ZHAO
1
;
XinLi JIANG
1
;
SiMeng FAN
1
;
Dan LI
1
;
Ying QIN
1
;
ZhiBin PENG
1
;
JianXing YU
2
;
NaiYing MAO
3
;
ZhongJie LI
1
Author Information
1. Division of Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
2. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
3. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
- Publication Type:Journal Article
- MeSH:
Antibodies, Neutralizing;
Antibodies, Viral;
COVID-19;
Humans;
Immunoglobulin M;
SARS-CoV-2
- From:
Chinese Journal of Epidemiology
2021;42(10):1750-1756
- CountryChina
- Language:Chinese
-
Abstract:
Domestic and foreign literatures related to the persistence of SARS-CoV-2 and the re-positive cases infected with SARS-CoV-2 were reviewed, and the characteristics and infectivity of the re-positive cases were analyzed to provide scientific evidence for the improvement of case management and the development of measures to stop the spread of SARS-CoV-2. Existing studies have shown that re-positive rate of SARS-CoV-2 ranged from 2.4% to 19.8%, the median of interval between re-positive detection and discharge was 4-15 days. Following the second course of the disease, the anti-SARS-CoV-2 IgM, IgG and IgA positive rates of the cases were 11.11%-86.08%, 52.00%-100.00% and 61.54%-100.00% respectively, the total antibody and neutralizing antibody positive rates were 98.72% and 88.46%. The viral load of the re-positive cases was lower than that in the initial infection. At least 3 380 re-positive cases have been reported globally. SARS-CoV-2 strains were isolated from the samples of 3 re-positive cases (1 immunodeficiency case and 2 cases with abnormal pulmonary imaging). There were close contacts that were infected by an asymptomatic case taking immunosuppressive agents. In conclusion, the infectivity of re-positive cases infected with SARS-CoV-2 is generally very low. Rare re-positive cases infected with SARS-CoV-2 might cause further transmission. The management approach for the re-positive cases can be based on the assessment of the individual transmission risk according to the pathogen detection results.
