Glutamatergic Neurons in the Caudal Zona Incerta Regulate Parkinsonian Motor Symptoms in Mice.
10.1007/s12264-021-00775-9
- Author:
Li-Xuan LI
1
;
Yu-Lan LI
1
;
Jin-Tao WU
1
;
Ji-Zhou SONG
2
;
Xiao-Ming LI
3
Author Information
1. Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
2. Department of Engineering Mechanics, Soft Matter Research Center, and Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Zhejiang University, Hangzhou, 310063, China.
3. Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. lixm@zju.edu.cn.
- Publication Type:Journal Article
- Keywords:
Caudal zona incerta;
Glutamate;
Parkinson's disease;
Parkinsonian motor symptoms;
Substantia nigra pars reticulata
- MeSH:
Animals;
Mice;
Neurons;
Parkinson Disease;
Parkinsonian Disorders;
Substantia Nigra;
Zona Incerta
- From:
Neuroscience Bulletin
2022;38(1):1-15
- CountryChina
- Language:English
-
Abstract:
Parkinson's disease (PD) is the second most common and fastest-growing neurodegenerative disorder. In recent years, it has been recognized that neurotransmitters other than dopamine and neuronal systems outside the basal ganglia are also related to PD pathogenesis. However, little is known about whether and how the caudal zona incerta (ZIc) regulates parkinsonian motor symptoms. Here, we showed that specific glutamatergic but not GABAergic ZIc
