Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice.
10.1007/s12264-021-00765-x
- Author:
Zhixin PENG
1
;
Xiaoheng LI
2
;
Jun LI
3
;
Yuan DONG
4
;
Yuhao GAO
2
;
Yajin LIAO
5
;
Meichen YAN
5
;
Zengqiang YUAN
6
;
Jinbo CHENG
7
Author Information
1. Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, 421001, China.
2. The Brain Science Center, Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Haidian District, Beijing, 100850, China.
3. Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China.
4. Institutes of Brain Sciences and Disease, Medical College, Qingdao University, Qingdao, 266071, China.
5. Center on Translational Neuroscience, College of Life and Environmental Science, Minzu University of China, Beijing, 100081, China.
6. Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, 421001, China. zqyuan@bmi.ac.cn.
7. Center on Translational Neuroscience, College of Life and Environmental Science, Minzu University of China, Beijing, 100081, China. cheng_jinbo@126.com.
- Publication Type:Journal Article
- Keywords:
Depression;
Dlg1;
Microglia;
Neuroinflammation
- MeSH:
Animals;
Depression/chemically induced*;
Inflammation;
Lipopolysaccharides/toxicity*;
Mice;
Mice, Inbred C57BL;
Mice, Knockout;
Microglia;
NF-kappa B;
Neuroinflammatory Diseases
- From:
Neuroscience Bulletin
2021;37(12):1671-1682
- CountryChina
- Language:English
-
Abstract:
Microglia-mediated neuroinflammation is widely perceived as a contributor to numerous neurological diseases and mental disorders including depression. Discs large homolog 1 (Dlg1), an adaptor protein, regulates cell polarization and the function of K
