cFos-ANAB: A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors.
10.1007/s12264-021-00744-2
- Author:
Fan WANG
1
;
Wenjie SUN
2
;
Lei CHANG
2
;
Kefang SUN
2
;
Leying HOU
2
;
Linna QIAN
2
;
Chaoyin JIN
2
;
Jiandong CHEN
2
;
Jiali PU
3
;
Panmeng YE
4
;
Shuang QIU
1
;
Jianhong LUO
1
;
Shumin DUAN
1
;
Baorong ZHANG
5
;
Zhihua GAO
6
;
Xiaojun HU
7
Author Information
1. Center for Neuroscience and Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
2. Medical Information Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
3. Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
4. Hangzhou Hikvision Digital Technology Co., Ltd, Hangzhou, 310053, China.
5. Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. brzhang@zju.edu.cn.
6. Center for Neuroscience and Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. zhihuagao@zju.edu.cn.
7. Medical Information Center, Zhejiang University School of Medicine, Hangzhou, 310058, China. xjhu@zju.edu.cn.
- Publication Type:Journal Article
- Keywords:
Behavior;
Brain nucleus;
Curated database;
Stimulus;
Visualization tools;
cFos expression
- MeSH:
Animals;
Fear;
Mice;
Neurons;
Proto-Oncogene Proteins c-fos;
Rats
- From:
Neuroscience Bulletin
2021;37(10):1441-1453
- CountryChina
- Language:English
-
Abstract:
cFos is one of the most widely-studied genes in the field of neuroscience. Currently, there is no systematic database focusing on cFos in neuroscience. We developed a curated database-cFos-ANAB-a cFos-based web tool for exploring activated neurons and associated behaviors in rats and mice, comprising 398 brain nuclei and sub-nuclei, and five associated behaviors: pain, fear, feeding, aggression, and sexual behavior. Direct relationships among behaviors and nuclei (even cell types) under specific stimulating conditions were constructed based on cFos expression profiles extracted from original publications. Moreover, overlapping nuclei and sub-nuclei with potentially complex functions among different associated behaviors were emphasized, leading to results serving as important clues to the development of valid hypotheses for exploring as yet unknown circuits. Using the analysis function of cFos-ANAB, multi-layered pictures of networks and their relationships can quickly be explored depending on users' purposes. These features provide a useful tool and good reference for early exploration in neuroscience. The cFos-ANAB database is available at www.cfos-db.net .
