Steroid Receptor Coactivator 3 Regulates Synaptic Plasticity and Hippocampus-dependent Memory.
10.1007/s12264-021-00741-5
- Author:
Hai-Long ZHANG
1
;
Bing ZHAO
2
;
Pin YANG
1
;
Yin-Quan DU
1
;
Wei HAN
1
;
Jianming XU
3
;
Dong-Min YIN
4
Author Information
1. Key Laboratory of Brain Functional Genomics, Ministry of Education and Shanghai, School of Life Science, East China Normal University, Shanghai, 200062, China.
2. MOE Frontiers Center for Brain Science, Institute for Translational Brain Research, Fudan University, Shanghai, 200032, China.
3. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
4. Key Laboratory of Brain Functional Genomics, Ministry of Education and Shanghai, School of Life Science, East China Normal University, Shanghai, 200062, China. dmyin@brain.ecnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Hippocampus;
Learning and memory;
N-Methyl-D-aspartate receptor;
SRC3;
Steroid receptor;
Synaptic plasticity
- MeSH:
Animals;
Hippocampus;
Long-Term Potentiation;
Mice;
Neuronal Plasticity;
Nuclear Receptor Coactivator 3/genetics*;
Synapses
- From:
Neuroscience Bulletin
2021;37(12):1645-1657
- CountryChina
- Language:English
-
Abstract:
Steroid hormones play important roles in brain development and function. The signaling of steroid hormones depends on the interaction between steroid receptors and their coactivators. Although the function of steroid receptor coactivators has been extensively studied in other tissues, their functions in the central nervous system are less well investigated. In this study, we addressed the function of steroid receptor coactivator 3 (SRC3) - a member of the p160 SRC protein family that is expressed predominantly in the hippocampus. While hippocampal development was not altered in Src3
