Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice.
10.1007/s12264-021-00731-7
- Author:
Xinyi ZHOU
1
;
Bifeng WU
2
;
Wenhao LIU
1
;
Qian XIAO
1
;
Wei HE
3
;
Ying ZHOU
4
;
Pengfei WEI
1
;
Xu ZHANG
5
;
Yue LIU
6
;
Jie WANG
6
;
Jufang HE
7
;
Zhigang ZHANG
1
;
Weidong LI
5
;
Liping WANG
1
;
Jie TU
8
Author Information
1. Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055, Shenzhen, China.
2. Department of Information Technology and Electrical Engineering, Zurich Swiss Federal Institute of Technology Zurich, 8092, Zurich, Switzerland.
3. Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061, USA.
4. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, 30322, USA.
5. Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, 200240, China.
6. University of Chinese of Academy of Sciences, Beijing, 100049, China.
7. Department of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong Kong.
8. Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055, Shenzhen, China. jie.tu@siat.ac.cn.
- Publication Type:Journal Article
- Keywords:
DISC1;
Nucleus accumbens;
Parvalbumin;
Risk avoidance
- MeSH:
Animals;
Interneurons/metabolism*;
Mice;
Mice, Transgenic;
Nerve Tissue Proteins/metabolism*;
Neurons/metabolism*;
Nucleus Accumbens/metabolism*;
Parvalbumins/metabolism*
- From:
Neuroscience Bulletin
2021;37(9):1325-1338
- CountryChina
- Language:English
-
Abstract:
A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk. In humans, a large proportion of mental disorders are accompanied by impairments in risk avoidance. One of the most important genes involved in mental disorders is disrupted-in-schizophrenia-1 (DISC1), and animal models in which this gene has some level of dysfunction show emotion-related impairments. However, it is not known whether DISC1 mouse models have an impairment in avoiding potential risks. In the present study, we used DISC1-N terminal truncation (DISC1-N
