The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction.
10.1007/s12264-021-00726-4
- Author:
Qian WANG
1
;
Ying KONG
1
;
Song LIN
1
;
Ding-Yu WU
1
;
Jian HU
1
;
Lang HUANG
1
;
Wen-Si ZANG
1
;
Xiao-Wen LI
1
;
Jian-Ming YANG
1
;
Tian-Ming GAO
2
Author Information
1. State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brian Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
2. State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brian Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. tgao@smu.edu.cn.
- Publication Type:Journal Article
- Keywords:
ATP;
Astrocyte;
Calorie restriction;
Depression;
IP3R2
- MeSH:
Adenosine Triphosphate;
Animals;
Antidepressive Agents/therapeutic use*;
Caloric Restriction;
Mice;
Mice, Knockout;
Prefrontal Cortex
- From:
Neuroscience Bulletin
2021;37(9):1303-1313
- CountryChina
- Language:English
-
Abstract:
Food deprivation can rescue obesity and overweight-induced mood disorders, and promote mood performance in normal subjects. Animal studies and clinical research have revealed the antidepressant-like effect of calorie restriction, but little is known about the mechanism of calorie restriction-induced mood modification. Previous studies have found that astrocytes modulate depressive-like behaviors. Inositol 1,4,5-trisphosphate receptor type 2 (IP3R2) is the predominant isoform in mediating astrocyte Ca
