Risk factors for urinary tract infection in kidney transplantation from brain death donor and its role in graft function.
10.11817/j.issn.1672-7347.2021.200666
- Author:
Qianqian YE
1
;
Lielin WU
2
;
Bisong ZHU
2
;
Gang ZHANG
2
;
Bo YANG
2
;
Peng JIN
2
;
Xiangrong ZHU
2
;
Jinliang XIE
2
;
Xiang DING
3
Author Information
1. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008. 313349415@qq.com.
2. Departmentof Organ Transplantation, Xiangya Hospital, Central South University, Changsha 410008.
3. Departmentof Organ Transplantation, Xiangya Hospital, Central South University, Changsha 410008. xiangding@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
brain death;
graft function;
kidney transplantatlon;
risk factors;
urinary tract infection
- MeSH:
Brain Death;
Female;
Humans;
Kidney Transplantation/adverse effects*;
Retrospective Studies;
Risk Factors;
Urinary Tract Infections/etiology*
- From:
Journal of Central South University(Medical Sciences)
2021;46(11):1220-1226
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:Urinary tract infection (UTI) is the most common infection complication after kidney transplantation, and the reports of the incidence vary greatly among different centers. This study aims to explore the risk factors for UTI after kidney transplantation with the donation from brain death (DBD) and the impact on graft function, thus to provide theoretical basis for comprehensive prevention and treatment of UTI after kidney transplantation.
METHODS:The clinical and laboratory data of DBD kidney transplantation from January 2017 to December 2018 in Xiangya Hospital, Central South University were collected and retrospectively analyzed. Patients were assigned into an UTI group and a non-UTI group. The base line characteristics, post-transplant complications, and graft function were compared between the 2 groups. Multivariate logistic regression was used to analyze the risk factors for UTI.
RESULTS:A total of 212 DBD kidney transplant recipients were enrolled in this study. UTI occurred in 44 (20.75%) patients after transplantation. The female, the time of indwelling catheter, and postoperative urinary fistula were independent risk factors for UTI after DBD kidney transplantation. A total of 19 strains of gram-positive bacteria, 12 strains of gram-negative bacteria , and 10 strains of fungi were isolated from the urine of 44 UTI patients. The UTI after kidney transplantation significantly increased time of hospital stay (
CONCLUSIONS:UTI after DBD kidney transplantation transplantation affects the renal function at 3 months and increases the patient's economic burden.
