Application and Prospect of Platelet Multi-Omics Technology in Study of Blood Stasis Syndrome.
10.1007/s11655-021-3349-y
- Author:
Ying LI
1
;
Ming-Qian SUN
1
;
Lei LI
1
;
Ye-Hao ZHANG
1
;
Lan MIAO
1
;
Jian-Xun LIU
2
Author Information
1. Beijing Key Laboratory of Pharmacology of Chinese Materia Region, Xiyuan Hospital, China Academy of Chinese Medical Sciences, National Clinical Research Center for Chinese Medicine Cardiology, Beijing, 100091, China.
2. Beijing Key Laboratory of Pharmacology of Chinese Materia Region, Xiyuan Hospital, China Academy of Chinese Medical Sciences, National Clinical Research Center for Chinese Medicine Cardiology, Beijing, 100091, China. liujx0324@sina.com.
- Publication Type:Journal Article
- Keywords:
blood stasis syndrome;
metabonomics;
platelet;
proteomics;
transcriptomics
- MeSH:
Blood Platelets;
Hemostasis;
Platelet Activation;
Proteomics;
Technology
- From:
Chinese journal of integrative medicine
2022;28(2):99-105
- CountryChina
- Language:English
-
Abstract:
The abnormality of platelet function plays an important role in the pathogenesis and evolution of blood stasis syndrome (BSS). The explanation of its mechanism is a key scientific issue in the study of cardiovascular and cerebrovascular diseases and treatment. System biology technology provides a good technical platform for further development of platelet multi-omics, which is conducive to the scientific interpretation of the biological mechanism of BSS. The article summarized the pathogenesis of platelets in BSS, the mechanism of action of blood activating and stasis resolving drugs, and the application of genomics, proteomics, and metabonomics in platelet research, and put forward the concept of "plateletomics in BSS". Through the combination and cross-validation of multi-omics technology, it mainly focuses on the clinical and basic research of cardiovascular and cerebrovascular diseases; through the interactive verification of multi-omics technology and system biology, it mainly focuses on the platelet function and secretion system. The article systematically explains the molecular biological mechanism of platelet activation, aggregation, release, and other stages in the formation and development of BSS, and provides a new research idea and method for clarifying the pathogenesis of BSS and the mechanism of action of blood activating and stasis resolving drugs.
