Chinese Herbal Medicine Adjusting Brain Microenvironment via Mediating Central Nervous System Lymphatic Drainage in Alzheimer's Disease.
10.1007/s11655-021-3342-5
- Author:
Xi-Bin ZHOU
1
;
Yu-Xing ZHANG
1
;
Chun-Xiang ZHOU
1
;
Jun-Jie MA
2
Author Information
1. Department of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China.
2. Department of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China. 290407@njucm.edu.cn.
- Publication Type:Review
- Keywords:
Alzheimer’s disease;
Chinese herbal medicine;
central lymphatic system
- MeSH:
Alzheimer Disease/drug therapy*;
Amyloid beta-Peptides;
Brain;
China;
Drugs, Chinese Herbal/therapeutic use*;
Humans
- From:
Chinese journal of integrative medicine
2022;28(2):176-184
- CountryChina
- Language:English
-
Abstract:
Due to its complex pathogenesis and lack of effective therapeutic methods, Alzheimer's disease (AD) has become a severe public health problem worldwide. Recent studies have discovered the function of central nervous system lymphatic drainage, which provides a new strategy for the treatment of AD. Chinese herbal medicine (CHM) has been considered as a cure for AD for hundreds of years in China, and its effect on scavenging β-amyloid protein in the brain of AD patients has been confirmed. In this review, the mechanism of central nervous system lymphatic drainage and the regulatory functions of CHM on correlation factors were briefly summarized. The advances in our understanding regarding the treatment of AD via regulating the central lymphatic system with CHM will promote the clinical application of CHM in AD patients and the discovery of new therapeutic drugs.
