- Author:
Bingjie WANG
1
;
Yinghui SHEN
1
;
Tianyu LIU
2
;
Li TAN
3
Author Information
- Publication Type:Journal Article
- Keywords: Acetylation of histone 3 lysine 27 (H3K27ac); Apolipoprotein A-I (ApoA-I); Breast cancer; Estrogen receptor α (ERα); p300
- From: Journal of Zhejiang University. Science. B 2021;22(12):1034-1044
- CountryChina
- Language:English
- Abstract: Apolipoprotein A-I (ApoA-I), the main protein component of high-density lipoprotein (HDL), plays a pivotal role in reverse cholesterol transport (RCT). Previous studies indicated a reduction of serum ApoA-I levels in various types of cancer, suggesting ApoA-I as a potential cancer biomarker. Herein, ectopically overexpressed ApoA-I in MDA-MB-231 breast cancer cells was observed to have antitumor effects, inhibiting cell proliferation and migration. Subsequent studies on the mechanism of expression regulation revealed that estradiol (E2)/estrogen receptor α (ERα) signaling activates