Basophils as a potential therapeutic target in cancer.

Jicheng Zhang; Hanlin Yin; Qiangda Chen; Guochao Zhao; Wenhui Lou; Wenchuan WU; Ning PU

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Basophils as a potential therapeutic target in cancer.

Author: Jicheng ZHANG ¹ ; Hanlin YIN ¹ ; Qiangda CHEN ¹ ; Guochao ZHAO ¹ ; Wenhui LOU ¹ ; Wenchuan WU ² ; Ning PU ³
Author Information

1. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
2. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. npu15@fudan.edu.cn, wu.wenchuan@zs-hospital.sh.cn.
3. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. npu15@fudan.edu.cn.
Publication Type:Journal Article
Keywords: Basophil; Cancer; Chemokine; Cytokine; Tumor microenvironment
From: Journal of Zhejiang University. Science. B 2021;22(12):971-984
CountryChina
Language:English
Abstract: Basophils, which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation, have been neglected by researchers in the past decades. Previous studies have revealed their vital roles in allergic diseases and parasitic infections. Intriguingly, recent studies even reported that basophils might be associated with cancer development, as activated basophils synthesize and release a variety of cytokines and chemokines in response to cancers. However, it is still subject to debate whether basophils function as tumor-protecting or tumor-promoting components; the answer may depend on the tumor biology and the microenvironment. Herein, we reviewed the role of basophils in cancers, and highlighted some potential and promising therapeutic strategies.