Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicine Pi-Yan-Ning: A case report.
10.1016/j.joim.2021.10.001
- Author:
Shu-Yi CHEN
1
;
Qun-Wei CHEN
1
;
Liu-Mei SHOU
1
;
Hong PAN
1
;
Shan-Ming RUAN
1
;
Zhe-Hao LIANG
2
;
Qi-Jin SHU
3
Author Information
1. Department of Oncology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China.
2. Department of Medical Ultrasonics, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China.
3. Department of Oncology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China. Electronic address: shuqjhz@163.com.
- Publication Type:Case Reports
- Keywords:
Case report;
Chinese herbal medicine;
Immunotherapy;
Stevens-Johnson syndrome;
Toxic epidermal necrolysis
- MeSH:
Drugs, Chinese Herbal/therapeutic use*;
Humans;
Immunologic Factors;
Incidence;
Male;
Middle Aged;
Skin;
Stevens-Johnson Syndrome/etiology*
- From:
Journal of Integrative Medicine
2021;19(6):555-560
- CountryChina
- Language:English
-
Abstract:
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare adverse cutaneous reaction with a low incidence and high mortality. Despite posing a serious threat to patients' health and lives, there is no high-quality evidence for a standard treatment regimen. Here we report the case of a 62-year-old man with stage IV pancreatic cancer who experienced immunotherapy-induced SJS/TEN. After consensus-based regular treatments at a local hospital, his symptoms became worse. Thus, he consented to receive Chinese herbal medicine (CHM) therapy. The affected parts of the patient were treated with the CHM Pi-Yan-Ning which was applied externally for 20 min twice a day. After 7 days of treatment, the dead skin began peeling away from the former lesions that had covered his hands, feet, and lips, indicating that skin had regenerated. After 12 days of treatment, the patient's skin was completely recovered. In this case, SJS/TEN was successfully treated with Pi-Yan-Ning, suggesting that there might be tremendous potential for the use of Pi-Yan-Ning in the treatment of severe skin reactions to drug treatments. Further basic investigations and clinical trials to explore the mechanism and efficacy are needed.
