Korean red ginseng decreases 1-methyl-4-phenylpyridinium-induced mitophagy in SH-SY5Y cells.
10.1016/j.joim.2021.09.005
- Author:
Hyongjun JEON
1
,
2
;
Hee-Young KIM
3
;
Chang-Hwan BAE
1
,
2
;
Yukyung LEE
1
,
2
;
Sungtae KOO
1
,
2
;
Seungtae KIM
1
,
4
Author Information
1. Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Gyeongsangnam-do 50612, Republic of Korea
2. Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, Gyeongsangnam-do 50612, Republic of Korea.
3. Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Gyeongsangnam-do 50612, Republic of Korea.
4. Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, Gyeongsangnam-do 50612, Republic of Korea. Electronic address: kimst@pusan.ac.kr.
- Publication Type:Journal Article
- Keywords:
1-Methyl-4-phenylpyridinium;
Apoptosis;
Korean red ginseng;
Mitophagy;
Parkinson’s disease
- MeSH:
1-Methyl-4-phenylpyridinium/toxicity*;
Apoptosis;
Cell Line, Tumor;
Mitochondria;
Mitophagy;
Panax;
Reactive Oxygen Species
- From:
Journal of Integrative Medicine
2021;19(6):537-544
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:Mitophagy is known to contribute towards progression of Parkinson's disease. Korean red ginseng (KRG) is a widely used medicinal herb in East Asia, and recent studies have reported that KRG prevents 1-methyl-4-phenylpyridinium ion (MPP
METHODS:SH-SY5Y cells were incubated with KRG for 24 h, and subsequently exposed to MPP
RESULTS:MPP
CONCLUSION:KRG effectively prevents MPP
