Emerging immunological strategies: recent advances and future directions.
10.1007/s11684-021-0886-x
- Author:
Hongyun ZHAO
1
;
Fan LUO
2
;
Jinhui XUE
1
;
Su LI
1
;
Rui-Hua XU
3
Author Information
1. Department of Clinical Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
2. Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
3. Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China. xurh@sysucc.org.cn.
- Publication Type:Review
- Keywords:
bispecific antibodies;
cancer immunotherapy;
cancer vaccines;
chimeric antigen receptor T therapy;
small molecules
- MeSH:
Antibodies, Bispecific/therapeutic use*;
Cancer Vaccines;
Humans;
Immunotherapy;
Neoplasms/therapy*;
Receptors, Chimeric Antigen;
T-Lymphocytes
- From:
Frontiers of Medicine
2021;15(6):805-828
- CountryChina
- Language:English
-
Abstract:
Immunotherapy plays a compelling role in cancer treatment and has already made remarkable progress. However, many patients receiving immune checkpoint inhibitors fail to achieve clinical benefits, and the response rates vary among tumor types. New approaches that promote anti-tumor immunity have recently been developed, such as small molecules, bispecific antibodies, chimeric antigen receptor T cell products, and cancer vaccines. Small molecule drugs include agonists and inhibitors that can reach the intracellular or extracellular targets of immune cells participating in innate or adaptive immune pathways. Bispecific antibodies, which bind two different antigens or one antigen with two different epitopes, are of great interest. Chimeric antigen receptor T cell products and cancer vaccines have also been investigated. This review explores the recent progress and challenges of different forms of immunotherapy agents and provides an insight into future immunotherapeutic strategies.
