Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19.

Lunzhi Yuan; Huachen Zhu; Ming Zhou; Jian MA; Rirong Chen; Liuqin YU; Wenjia Chen; Wenshan Hong; Jia Wang; Yao Chen; Kun WU; Wangheng Hou; Yali Zhang; Shengxiang GE; Yixin Chen; Quan Yuan; Qiyi Tang; Tong Cheng; Yi Guan; Ningshao Xia

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Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19.

Author: Lunzhi YUAN ¹ ; Huachen ZHU ² ; Ming ZHOU ¹ ; Jian MA ¹ ; Rirong CHEN ² ; Liuqin YU ² ; Wenjia CHEN ² ; Wenshan HONG ² ; Jia WANG ² ; Yao CHEN ¹ ; Kun WU ¹ ; Wangheng HOU ¹ ; Yali ZHANG ¹ ; Shengxiang GE ¹ ; Yixin CHEN ¹ ; Quan YUAN ¹ ; Qiyi TANG ³ ; Tong CHENG ⁴ ; Yi GUAN ⁵ ; Ningshao XIA ⁶
Author Information

1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361000, China.
2. State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.
3. Department of Microbiology, Howard University College of Medicine, Washington, DC, 20059, USA. qiyi.tang@howard.edu.
4. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361000, China. tcheng@xmu.edu.cn.
5. State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China. yguan@hku.hk.
6. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361000, China. nsxia@xmu.edu.cn.
Publication Type:Research Support, Non-U.S. Gov't
MeSH: Animals; Antibodies, Neutralizing/biosynthesis*; Antibodies, Viral/biosynthesis*; Body Weight/immunology*; COVID-19/virology*; Disease Models, Animal; Disease Progression; Humans; Immunohistochemistry; Lung/virology*; Male; Mesocricetus; Nasal Cavity/virology*; RNA, Viral/immunology*; SARS-CoV-2/pathogenicity*; Severity of Illness Index; Viral Load
From: Protein & Cell 2022;13(1):72-77
CountryChina
Language:English