miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition.
10.1038/s41368-021-00148-y
- Author:
Han ZHENG
1
;
Ning WANG
1
;
Le LI
2
;
Lihua GE
1
;
Haichao JIA
3
;
Zhipeng FAN
4
Author Information
1. Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.
2. Tsinghua University Hospital, Stomatological Disease Prevention and Control Center, Tsinghua University, Beijing, China.
3. Department of Orthodontics, Capital Medical University School of Stomatology, Beijing, China. haichaojia@hotmail.com.
4. Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China. zpfan@ccmu.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Cell Differentiation;
Histone-Lysine N-Methyltransferase;
Humans;
Hypoxia;
Methyltransferases;
MicroRNAs
- From:
International Journal of Oral Science
2021;13(1):41-41
- CountryChina
- Language:English
-
Abstract:
Human dental pulp stem cells (DPSCs) have emerged as an important source of stem cells in the tissue engineering, and hypoxia will change various innate characteristics of DPSCs and then affect dental tissue regeneration. Nevertheless, little is known about the complicated molecular mechanisms. In this study, we aimed to investigate the influence and mechanism of miR-140-3p on DPSCs under hypoxia condition. Hypoxia was induced in DPSCs by Cobalt chloride (CoCl
