The effects of altered BMP4 signaling in first branchial-arch-derived murine embryonic orofacial tissues.
10.1038/s41368-021-00142-4
- Author:
Jue XU
1
;
Meiling CHEN
2
;
Yanan YAN
2
;
Qiaoxue ZHAO
2
;
Meiying SHAO
3
;
Zhen HUANG
4
Author Information
1. West China School of Public Health and Department of Stomatology, West China Fourth Hospital, Sichuan University, Chengdu, China.
2. Southern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neuro Biology, College of Life Sciences, Fujian Normal University, Fuzhou, China.
3. West China School of Public Health and Department of Stomatology, West China Fourth Hospital, Sichuan University, Chengdu, China. shaomeiying2013@163.com.
4. Southern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neuro Biology, College of Life Sciences, Fujian Normal University, Fuzhou, China. zhuang@fjnu.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Animals;
Bone Morphogenetic Protein 4;
Branchial Region;
Mesenchymal Stem Cells;
Mice;
Skull
- From:
International Journal of Oral Science
2021;13(1):40-40
- CountryChina
- Language:English
-
Abstract:
The first branchial arch (BA1), which is derived from cranial neural crest (CNC) cells, gives rise to various orofacial tissues. Cre mice are widely used for the determination of CNC and exploration of gene functions in orofacial development. However, there is a lack of Cre mice specifically marked BA1's cells. Pax2-Cre allele was previously generated and has been widely used in the field of inner ear development. Here, by compounding Pax2-Cre and R26R-mTmG mice, we found a specific expression pattern of Pax2
