Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1.

Author: Na KONG ¹ ; Xiaying CHEN ¹ ; Jiao FENG ¹ ; Ting DUAN ¹ ; Shuiping LIU ¹ ; Xueni SUN ¹ ; Peng CHEN ¹ ; Ting PAN ¹ ; Lili YAN ¹ ; Ting JIN ¹ ; Yu XIANG ¹ ; Quan GAO ¹ ; Chengyong WEN ¹ ; Weirui MA ¹ ; Wencheng LIU ¹ ; Mingming ZHANG ¹ ; Zuyi YANG ¹ ; Wengang WANG ¹ ; Ruonan ZHANG ¹ ; Bi CHEN ¹ ; Tian XIE ¹ ; Xinbing SUI ¹ ; Wei TAO ²
Author Information

1. College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China.
2. Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Publication Type:Journal Article
Keywords: Baicalin; Bladder cancer; Deferoxamine; FTH1; Ferroptosis
From: Acta Pharmaceutica Sinica B 2021;11(12):4045-4054
CountryChina
Language:English
Abstract: Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation. Currently, the therapeutic role of ferroptosis on cancer is gaining increasing interest. Baicalin an active component in