A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease.

Author: Ting LEI ¹ ; Zhihang YANG ¹ ; Xue XIA ¹ ; Yuxiu CHEN ¹ ; Xiaotong YANG ¹ ; Rou XIE ¹ ; Fan TONG ¹ ; Xiaolin WANG ² ; Huile GAO ¹
Author Information

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
2. School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Publication Type:Journal Article
Keywords: Alzheimer's disease; Anti-inflammatory; Autophagy; Aβ-capturing; Blood‒brain barrier transcytosis; Lesion targeting; Microenvironment modulation; ROS-responsive
From: Acta Pharmaceutica Sinica B 2021;11(12):4032-4044
CountryChina
Language:English
Abstract: Insurmountable blood‒brain barrier (BBB) and complex pathological features are the key factors affecting the treatment of Alzheimer's disease (AD). Poor accumulation of drugs in lesion sites and undesired effectiveness of simply reducing A