Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy.

Yancheng Tang; Liming Wang; Tao YI; Jun XU; Jigang Wang; Jiang-jiang Qin; Qilei Chen; Ka-man Yip; Yihang Pan; Peng Hong; Yingying LU; Han-ming Shen; Hu-biao Chen

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Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy.

Author: Yancheng TANG ¹ ; Liming WANG ² ; Tao YI ¹ ; Jun XU ¹ ; Jigang WANG ³ ; Jiang-Jiang QIN ⁴ ; Qilei CHEN ¹ ; Ka-Man YIP ¹ ; Yihang PAN ⁵ ; Peng HONG ⁵ ; Yingying LU ⁵ ; Han-Ming SHEN ⁶ ; Hu-Biao CHEN ¹
Author Information

1. School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, China.
2. School of Biomedical Sciences, Hunan University, Changsha 410082, China.
3. Artemisinin Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China.
4. The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China.
5. Department of Medical Research, Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.
6. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Publication Type:Journal Article
Keywords: Apoptosis; Combination therapy; Magnolol; PINK1‒Parkin-mediated mitophagy; Tumor suppression
From: Acta Pharmaceutica Sinica B 2021;11(12):3966-3982
CountryChina
Language:English
Abstract: Mitochondria as a signaling platform play crucial roles in deciding cell fate. Many classic anticancer agents are known to trigger cell death through induction of mitochondrial damage. Mitophagy, one selective autophagy, is the key mitochondrial quality control that effectively removes damaged mitochondria. However, the precise roles of mitophagy in tumorigenesis and anticancer agent treatment remain largely unclear. Here, we examined the functional implication of mitophagy in the anticancer properties of magnolol, a natural product isolated from herbal