Bile acid homeostasis in female mice deficient in
10.1016/j.apsb.2021.05.023
- Author:
Daniel RIZZOLO
1
;
Bo KONG
1
;
Rulaiha E TAYLOR
1
;
Anita BRINKER
2
;
Michael GOEDKEN
3
;
Brian BUCKLEY
1
;
Grace L GUO
1
Author Information
1. Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
2. Environmental and Occupational Health Institute, Rutgers University, Piscataway, NJ 08854, USA.
3. Office of Research and Economic Development, Research Pathology Services, Rutgers University, Piscataway, NJ 08854, USA.
- Publication Type:Journal Article
- Keywords:
ALP, alkaline phosphatase;
ALT, alanine aminotransferase;
ASBT, apical sodium-dependent BA transporter;
AST, aspartate transaminase;
BA, bile acid;
BSEP, bile salt export pump;
Bile acids;
CA, cholic acid;
CDCA, chenodeoxycholic acid;
CYP27A1;
CYP27A1, sterol 27-hydroxylase;
CYP2C70, cytochrome P450 2C70;
CYP7A1;
CYP7A1, cholesterol 7α-hydroxylase;
CYP7B1, 25-hydroxycholesterol 7-alpha-hydroxylase;
CYP8B1, sterol 12α-hydroxylase;
DCA, deoxycholic acid;
DKO, double knockout;
FXR, farnesoid X receptor;
Farnesoid X receptor;
Female;
Fibroblast growth factor 15;
IBABP, intestinal BA-binding protein;
LCA, lithocholic acid;
NTCP, sodium taurocholate cotransporting polypeptide;
OATP, organic anion transporters;
OSTα/β, organic solute transporters alpha and beta;
WT, wild type;
βMCA, beta muricholic acid
- From:
Acta Pharmaceutica Sinica B
2021;11(12):3847-3856
- CountryChina
- Language:English
-
Abstract:
Bile acids (BAs) are amphipathic molecules important for metabolism of cholesterol, absorption of lipids and lipid soluble vitamins, bile flow, and regulation of gut microbiome. There are over 30 different BA species known to exist in humans and mice, which are endogenous modulators of at least 6 different membrane or nuclear receptors. This diversity of ligands and receptors play important roles in health and disease; however, the full functions of each individual BA
