Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver.
10.1016/j.apsb.2021.10.014
- Author:
Jian JIN
1
;
Banrida WAHLANG
2
;
Monika THAPA
3
;
Kimberly Z HEAD
2
;
Josiah E HARDESTY
2
;
Sudhir SRIVASTAVA
4
;
Michael L MERCHANT
5
;
Shesh N RAI
6
;
Russell A PROUGH
3
;
Matthew C CAVE
1
Author Information
1. Department of Pharmacology & Toxicology, the University of Louisville School of Medicine, Louisville, KY 40202, USA.
2. Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, the University of Louisville School of Medicine, Louisville, KY 40202, USA.
3. Department of Biochemistry and Molecular Genetics, the University of Louisville School of Medicine, Louisville, KY 40202, USA.
4. Department of Bioinformatics and Biostatistics, the School of Public Health and Information Sciences, the University of Louisville, Louisville, KY 40202, USA.
5. The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY 40202, USA.
6. Superfund Research Center, the University of Louisville, Louisville, KY 40202, USA.
- Publication Type:Journal Article
- Keywords:
AHR;
AHR, aryl hydrocarbon receptor;
ALT, alanine transaminase;
ANOVA, analysis of variance;
AST, aspartate transaminase;
AUC, area under the curve;
CAR, constitutive androstane receptor;
CD36, cluster of differentiation 36;
CYP, cytochrome P450;
EPF, enrichment by protein function;
Endocrine disruption;
Environmental liver disease;
FDR, false discovery rate;
FGF21, fibroblast growth factor 21;
GCR, glucocorticoid receptor;
GO, gene ontology;
H&E, hematoxylin-eosin;
HDL, high-density lipoprotein;
HFD, high fat diet;
IGF1, insulin-like growth factor 1;
IL-6, interleukin 6;
IPF, interaction by protein function;
LDL, low-density lipoprotein;
MCP-1, monocyte chemoattractant protein-1;
MUP, major urinary protein;
NAFLD, non-alcoholic fatty liver disease;
NFKBIA, nuclear factor kappa-inhibitor alpha;
Nonalcoholic fatty liver disease;
PAI-1, plasminogen activator inhibitor-1;
PCB, polychlorinated biphenyl;
PCB126;
PLIN2, perilipin-2;
PNPLA3, patatin-like phospholipase domain-containing protein 3;
PPARα, peroxisome proliferator-activated receptor alpha;
PXR, pregnane-xenobiotic receptor;
Perilipin-2;
Pheromones;
SGK1, serum/glucocorticoid regulated kinase;
TAFLD, toxicant-associated fatty liver disease;
TASH, toxicant-associated steatohepatitis;
TAT, tyrosine aminotransferase;
TMT, tandem mass tag;
VLDL, very low-density lipoprotein;
WT, wild type;
ZFP125, zinc finger protein 125;
miR, microRNA;
nHDLc, non-HDL cholesterol
- From:
Acta Pharmaceutica Sinica B
2021;11(12):3806-3819
- CountryChina
- Language:English
-
Abstract:
Dioxin-like molecules have been associated with endocrine disruption and liver disease. To better understand aryl hydrocarbon receptor (AHR) biology, metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or whole-body genetic ablation of this receptor. Male wild type (WT) and
