Tricarbocyclic core formation of tyrosine-decahydrofluorenes implies a three-enzyme cascade with XenF-mediated sigmatropic rearrangement as a prerequisite.

Author: Zhiguo LIU ¹ ; Wei LI ² ; Peng ZHANG ² ; Jie FAN ² ; Fangbo ZHANG ¹ ; Caixia WANG ¹ ; Shuming LI ³ ; Yi SUN ¹ ; Shilin CHEN ¹ ; Wenbing YIN ²
Author Information

1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
2. State Key Laboratory of Mycology, CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
3. Institut für Pharmazeutische Biologie und Biotechnologie, Fachbereich Pharmazie, Philipps-Universität Marburg, Marburg 35037, Germany.
Publication Type:Journal Article
Keywords: Biosynthesis; Heterologous expression; PKS−NRPS; Tyrosine-decahydrofluorene; Xenoacremone
From: Acta Pharmaceutica Sinica B 2021;11(11):3655-3664
CountryChina
Language:English
Abstract: Tyrosine-decahydrofluorene derivatives feature a fused [6.5.6] tricarbocyclic core and a 13-membered