Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy.
10.1016/j.apsb.2021.04.005
- Author:
Shenwu ZHANG
1
;
Yuequan WANG
1
;
Zhiqiang KONG
1
;
Xuanbo ZHANG
1
;
Bingjun SUN
1
;
Han YU
1
;
Qin CHEN
2
;
Cong LUO
1
;
Jin SUN
1
;
Zhonggui HE
1
Author Information
1. Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
- Publication Type:Journal Article
- Keywords:
ACQ, aggregation caused quenching;
ALT, alanine aminotransferase;
AST, aspartate aminotransferase;
BUN, blood urine nitrogen;
CRE, creatinine;
Core-matched;
DCFH-DA, 2′,7′-dichlorofluorescein diacetate;
DDS, drug delivery system;
FBS, fetal bovine serum;
Imaging-guided;
NPs, nanoparticles;
NaCl, sodium chloride;
Nanoassembly;
PBS, phosphate buffer solution;
PDANs, pure drug-assembled nanomedicines;
PDT, photodynamic therapy;
PPa, pyropheophorbide a;
PS, photosensitizer;
Photodynamic therapy;
Pure drug-assembled nanomedicines;
Pure photosensitizer;
Pyropheophorbide a;
ROS, reactive oxygen species;
SDS, sodium dodecyl sulfate;
SOSG, Singlet Oxygen Sensor Green Reagent;
Self-assembly;
nano-DDS, nanoparticulate drug delivery systems
- From:
Acta Pharmaceutica Sinica B
2021;11(11):3636-3647
- CountryChina
- Language:English
-
Abstract:
Pure drug-assembled nanomedicines (PDANs) are currently under intensive investigation as promising nanoplatforms for cancer therapy. However, poor colloidal stability and less tumor-homing ability remain critical unresolved problems that impede their clinical translation. Herein, we report a core-matched nanoassembly of pyropheophorbide a (PPa) for photodynamic therapy (PDT). Pure PPa molecules are found to self-assemble into nanoparticles (NPs), and an amphiphilic PEG polymer (PPa-PEG
