Self-assembled ternary hybrid nanodrugs for overcoming tumor resistance and metastasis.

Author: Xu CHENG ¹ ; Dapeng LI ¹ ; Jiaxi XU ¹ ; Bing WEI ² ; Qin FANG ¹ ; Longshun YANG ¹ ; Yanbing XUE ¹ ; Xin WANG ¹ ; Rupei TANG ¹
Author Information

1. Engineering Research Center for Biomedical Materials, Anhui Key Laboratory of Modern Biomanufacturing, School of Life Sciences, Anhui University, Hefei 230601, China.
2. School of Biology and Food Engineering, Fuyang Normal University, Fuyang 236037, China.
Publication Type:Journal Article
Keywords: Charge reversal; Drugs dimer; Inflammation; Metastasis; Multidrug resistance; Polyethyleneimine; Proton sponge; Redox sensitive
From: Acta Pharmaceutica Sinica B 2021;11(11):3595-3607
CountryChina
Language:English
Abstract: Traditional chemotherapy exhibits a certain therapeutic effect toward malignant cancer, but easily induce tumor multidrug resistance (MDR), thereby resulting in the progress of tumor recurrence or metastasis. In this work, we deigned ternary hybrid nanodrugs (PEI/DOX@CXB-NPs) to simultaneously combat against tumor MDR and metastasis.