Protocatechuic aldehyde protects cardiomycoytes against ischemic injury
10.1016/j.apsb.2021.03.021
- Author:
Xunxun WU
1
;
Lian LIU
1
;
Qiuling ZHENG
2
;
Haiping HAO
1
;
Hui YE
1
;
Ping LI
1
;
Hua YANG
1
Author Information
1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
2. College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- Keywords:
Apoptosis;
CETSA, cellular thermal shift assay;
CK-MB, creatine kinase isoenzyme-MB;
DARTS, drug affinity responsive target stability;
Heart ischemia;
ISO, isoprenaline;
LDH, lactate dehydrogenase;
Mitochondrial damage;
Myocardial infarction;
NRVMs, neonatal rat ventricular myocytes;
Nuclear translocation;
OGD, oxygen and glucose deprivation;
PCA, protocatechuic aldehyde;
PKM2;
PKM2, pyruvate kinase isoform M2;
Protocatechuic aldehyde;
ROS, reactive oxygen species;
TCF4;
TCF4, T-cell factor 4;
TUNEL, deoxynucleotidyl transferase-mediated dUTP nick end-labeling;
shRNA, short hairpin RNA;
β-Catenin
- From:
Acta Pharmaceutica Sinica B
2021;11(11):3553-3566
- CountryChina
- Language:English
-
Abstract:
Rescuing cells from stress damage emerges a potential therapeutic strategy to combat myocardial infarction. Protocatechuic aldehyde (PCA) is a major phenolic acid in Chinese herb Danshen (
