Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease.

Author: Xiaojiaoyang LI ¹ ; Junde GE ² ; Yajing LI ¹ ; Yajie CAI ¹ ; Qi ZHENG ¹ ; Nana HUANG ² ; Yiqing GU ¹ ; Qi HAN ¹ ; Yunqian LI ¹ ; Rong SUN ² ; Runping LIU ¹
Author Information

1. Beijing University of Chinese Medicine, Beijing 100029, China.
2. The Second Hospital of Shandong University, Shandong University, Ji'nan 250033, China.
Publication Type:Journal Article
Keywords: Lipid metabolism; Lipidome; Nonalcoholic fatty liver disease; Saikosaponin; Transcriptome
From: Acta Pharmaceutica Sinica B 2021;11(11):3527-3541
CountryChina
Language:English
Abstract: Nonalcoholic fatty liver disease (NAFLD) has become one of the most prominent causes of chronic liver diseases and malignancies. However, few therapy has been approved. Radix Bupleuri (RB) is the most frequently used herbal medicine for the treatment of liver diseases. In the current study, we aim to systemically evaluate the therapeutic effects of saikosaponin A (SSa) and saikosaponin D (SSd), the major bioactive monomers in RB, against NAFLD and to investigate the underlying mechanisms. Our results demonstrated that both SSa and SSd improved diet-induced NAFLD. Integrative lipidomic and transcriptomic analysis revealed that SSa and SSd modulated glycerolipid metabolism by regulating related genes, like