Magnetic resonance spectroscopy features of the thalamus and the cerebellum and their association with clinical features in children with autism spectrum disorder: a prospective study.
10.7499/j.issn.1008-8830.2108137
- Author:
Qian-Qian KANG
1
;
Xu LI
1
;
Guang-Lei TONG
1
;
Ya-Lan FAN
1
;
Lei SHI
1
Author Information
1. Anhui Hospital Affiliated to Children's Hospital of Fudan University/Anhui Children's Hospital, Hefei 230022, China.
- Publication Type:Journal Article
- Keywords:
Autism spectrum disorder;
Cerebellum;
Child;
Magnetic resonance spectroscopy;
Thalamus
- MeSH:
Autism Spectrum Disorder/diagnostic imaging*;
Cerebellum/diagnostic imaging*;
Child;
Choline;
Humans;
Magnetic Resonance Spectroscopy;
Prospective Studies;
Thalamus/diagnostic imaging*
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(12):1250-1255
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the changes in biochemical metabolites in the thalamus and the cerebellum and their association with clinical features in children with autism spectrum disorder (ASD).
METHODS:In this prospective study, magnetic resonance spectroscopy (MRS) with point-resolved spatial selection was used to analyze the thalamus and the cerebellum at both sides in 50 children with ASD aged 2-6 years. Creatine (Cr) was as the internal standard to measure the relative values of N-acetylaspartate (NAA)/Cr, choline (Cho)/Cr, myoinositol (MI)/Cr, and glutamine and glutamate complex (Glx)/Cr, and the differences in metabolites and their association with clinical symptoms were compared.
RESULTS:In the children with ASD, NAA/Cr in the left thalamus was positively correlated with the scores of hearing-language and hand-eye coordination in the Griffiths Development Scales-Chinese (
CONCLUSIONS:There are metabolic disorders in the cerebellum and the thalamus in children with ASD, and there is a correlation between the changes of metabolites in the left cerebellum and the left thalamus. Some metabolic indexes are related to the clinical symptoms of ASD. MRS may reveal the pathological basis of ASD and provide a basis for diagnosis and prognosis assessment of ASD as a noninvasive and quantitative detection method.
