Recent research on the influence of intrauterine growth restriction on the structure and function of the nervous system.
10.7499/j.issn.1008-8830.2108044
- Author:
Yi-Jia ZHANG
1
Author Information
1. Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China.
- Publication Type:Journal Article
- Keywords:
Intrauterine growth restriction;
Nervous system;
Prognosis;
Small for gestational age infant
- MeSH:
Brain;
Child;
Female;
Fetal Growth Retardation;
Gestational Age;
Humans;
Infant;
Infant, Newborn;
Infant, Premature;
Infant, Small for Gestational Age;
Pregnancy
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(11):1184-1189
- CountryChina
- Language:English
-
Abstract:
Intrauterine growth restriction (IUGR) is caused by many factors, and most newborns with IUGR are small for gestational age (SGA). SGA infants have a relatively high risk of death and disease in the perinatal period, and the nervous system already has structural changes in the uterus, including the reduction of brain volume and gray matter volume, accompanied by abnormal imaging and pathological changes. IUGR fetuses undergo intrauterine blood flow redistribution to protect brain blood supply, and there are still controversies over the clinical effect of brain protection mechanism. SGA infants have a relatively high risk of abnormal cognitive, motor, language, and behavioral functions in the neonatal period and childhood, and preterm infants tend to have a higher degree of neurological impairment than full-term infants. Early intervention may help to improve the function of the nervous system.
