Association between
10.7499/j.issn.1008-8830.2108054
- Author:
Ming-Xuan CAI
1
;
Bing WEI
1
;
Shi-E LIAO
1
;
Jin-Yue FU
1
;
Ya-Jun LIU
1
;
Ling-Xue LI
1
Author Information
1. General Hospital of the Northern Theater of the Chinese People's Liberation Army, Shenyang 110016, China.
- Publication Type:Journal Article
- Keywords:
ADRB2 gene;
Asthma;
Child;
Haplotype;
Single nucleotide polymorphism;
Susceptibility
- MeSH:
Asthma/genetics*;
Case-Control Studies;
Child;
Genetic Predisposition to Disease;
Genotype;
Haplotypes;
Humans;
Polymorphism, Single Nucleotide;
Receptors, Adrenergic, beta-2/genetics*;
Regulatory Sequences, Nucleic Acid
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(11):1132-1140
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the association of β2-drenergic receptor (
METHODS:A total of 143 children with asthma who attended the hospital from October 2016 to October 2020 were enrolled as the asthma group, among whom 61 children had mild symptoms (mild group) and 82 children had moderate-to-severe symptoms (moderate-to-severe group). A total of 137 healthy children were enrolled as the control group. Peripheral venous blood samples were collected from the two groups. The SNaPshot SNP technique was used to analyze the SNP and haplotypes of the
RESULTS:Polymorphisms were observed in the
CONCLUSIONS:SNP/haplotype of the
