Effect of different maintenance doses of caffeine citrate on ventilator weaning in very preterm infants with respiratory distress syndrome: a prospective randomized controlled trial.
10.7499/j.issn.1008-8830.2107167
- Author:
Xiao-Lan LI
1
;
Yue-Ju CAI
;
Zhe ZHANG
;
Jian LI
;
Xiao-Wen CHEN
;
Yan-Yan SONG
1
;
Wei ZHOU
Author Information
1. Department of Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.
- Publication Type:Randomized Controlled Trial
- Keywords:
Caffeine citrate;
Preterm infant;
Respiratory distress syndrome;
Ventilator weaning
- MeSH:
Caffeine;
Citrates;
Humans;
Infant;
Infant, Newborn;
Infant, Premature;
Prospective Studies;
Respiratory Distress Syndrome, Newborn/therapy*;
Ventilator Weaning
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(11):1097-1102
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the effect of different maintenance doses of caffeine citrate on the success rate of ventilator weaning in very preterm infants (gestational age of ≤32 weeks) with respiratory distress syndrome (RDS).
METHODS:A total of 162 preterm infants with RDS who were admitted to the hospital from January 2016 to December 2018 were enrolled in this prospective trial. These infants had a gestational age of ≤32 weeks and required invasive mechanical ventilation. They were randomly divided into a high-dose caffeine group and a low-dose caffeine group, with 81 infants in each group. Within 6 hours after birth, both groups were given caffeine at a dose of 20 mg/kg. After 24 hours, the high- and low-dose caffeine groups were given caffeine at a maintenance dose of 10 mg/kg and 5 mg/kg, respectively. The two groups were compared in terms of re-intubation rate within 48 hours after ventilator weaning, durations of ventilation and oxygen therapy, enteral feeding, weight gain, and the incidence rates of complications and adverse reactions during hospitalization.
RESULTS:The high-dose caffeine group had a significantly lower re-intubation rate within 48 hours after ventilator weaning than the low-dose caffeine group (
CONCLUSIONS:A high maintenance dose of caffeine can safely and effectively reduce the incidence rate of apnea after ventilator weaning and the failure rate of ventilator weaning in RDS preterm infants with a gestational age of ≤32 weeks, and therefore, it holds promise for clinical application.
