Recent research on myositis-specific autoantibodies in juvenile dermatomyositis.
10.7499/j.issn.1008-8830.2106011
- Author:
Lu HE
1
Author Information
1. Department of Pediatrics, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China (Hu X-F, Email: xfhu2007@163.com).
- Publication Type:Review
- Keywords:
Anti-MDA5 antibody;
Anti-Mi-2 antibody;
Anti-NXP2 antibody;
Anti-SAE antibody;
Anti-TIF1-γ antibody;
Child;
Clinical phenotype;
Juvenile dermatomyositis;
Serological antibody
- MeSH:
Autoantibodies;
Dermatomyositis;
Humans;
Lung Diseases, Interstitial/etiology*;
Myositis;
Prognosis
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(10):1064-1068
- CountryChina
- Language:English
-
Abstract:
Juvenile dermatomyositis (JDM) is an autoimmune disease manifesting as proximal muscle weakness and skin rash and can involve multiple systems and visceral organs. Myositis-specific autoantibodies (MSAs) are highly associated with various complications and prognosis in JDM. Patients with anti-Mi-2 antibodies tend to have good prognosis and typical clinical symptoms. Patients with anti-MDA5 antibodies often have diffuse interstitial lung disease and skin ulcer, with mild symptoms of myositis. Patients with anti-NXP2 antibodies often have calcinosis, and such antibodies are associated with gastrointestinal bleeding and perforation. Patients with anti-TIF1-γ antibodies have diffuse and refractory skin lesions. Anti-SAE antibodies are rarely detected in children, with few reports of such cases. This article reviews the features of clinical phenotypes in JDM children with these five types of MSAs, so as to provide a basis for the clinical treatment and follow-up management of children with JDM.
