Value of serum miR-922 and miR-506 expression levels in the diagnosis and prognostic assessment of childhood acute lymphoblastic leukemia.
10.7499/j.issn.1008-8830.2105148
- Author:
Yi-Yue ZHU
1
;
Ri-Nuan WU
;
Xia LI
1
;
Xiang-Bi CHEN
1
Author Information
1. Department of Pediatrics, Sanya Maternal and Child Health Hospital, Sanya, Hainan 572000, China (Email: zhuyiyue2705@163.com).
- Publication Type:Journal Article
- Keywords:
Acute lymphoblastic leukemia;
Child;
Diagnostic value;
Prognosis;
miR-506;
miR-922
- MeSH:
Biomarkers, Tumor;
Child;
Humans;
Kaplan-Meier Estimate;
MicroRNAs/genetics*;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics*;
Prognosis;
ROC Curve
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(10):1021-1026
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the value of serum miR-922 and miR-506 expression levels in the diagnosis and prognostic assessment of childhood acute lymphoblastic leukemia (ALL).
METHODS:A total of 132 children with ALL (ALL group) and 80 healthy children (healthy control group) were prospectively selected in this study. Quantitative real-time polymerase chain reaction was used to measure the expression levels of serum miR-922 and miR-506 in both groups. Receiver operating characteristic (ROC) curves were plotted to analyze the diagnostic value of miR-922 and miR-506 for childhood ALL. The Kaplan-Meier method was used to plot survival curves, and multivariate COX regression models were used to analyze the risk factors for poor prognosis in children with ALL.
RESULTS:The ALL group had significantly higher expression levels of serum miR-922 and miR-506 than the control group (
CONCLUSIONS:The expression levels of miR-922 and miR-506 are of good value in the diagnosis and prognostic assessment of childhood ALL.
